Cytokine Storm

The cytokine storm is an inappropriate and extreme immune response that is caused by rapidly proliferating and highly activated T-cells or natural killer (NK) cells. These cells are themselves activated by infected macrophages. The cytokine storm must be treated and suppressed or lethality can result.

Related Research project
We started two closely related research projects which focus on the possibilities of a Cytokine Storm mitigating effect of our compounds in Ebola and Severe Dengue.
Up to now, at least two main mechanisms mediated by the DDX3 RNA helicase are of particular relevance to Dengue fever, given its role in viral RNA replication and the induction of cytokine and interleukin expression. Reducing the viral load and spread throughout the body, DDX3 inhibitors will mitigate the severity of the infection and the co-morbidity. In addition, as DDX3 mediates the induction of specific cytokines and interleukins, a Cytokine Storm neutralizing effect can be anticipated as well